Peripheral artery disease causes leg pain, claudication, and tissue ischemia due to arterial narrowing. EECP stimulates angiogenesis and collateral vessel formation, improving blood flow without surgery.
Cuffs inflate in diastole, driving a wave of blood retrograde through the aorta — increasing coronary perfusion pressure and delivering oxygen-rich blood to ischemic tissue.
Increased shear stress on the endothelium triggers release of nitric oxide — the body's master vasodilator — improving vessel tone and reducing inflammation.
Repeated sessions stimulate VEGF and other growth factors, promoting the formation of new collateral blood vessels in ischemic tissue.
Endothelial function improves throughout the body — not just at the heart — producing benefits in peripheral, cerebral, and microvascular circulation.
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Peer-reviewed studies, RCTs, and meta-analyses from the EECP clinical evidence library relevant to Peripheral Artery Disease (PAD). Click any title to access the source.